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A young doctor in a US hospital administers a powerful and untested cocktail of drugs to a coma victim. But instead of curing him, it triggers a powerful “out-of-body” experience and enables the patient - a depraved and dangerous loner - to inhabit other people’s bodies and, through them, take revenge on the bullying medical students who were accidentally responsible for his condition. The doctor, who was herself a part of this group, is also targeted and as her colleagues are singled out and relentlessly picked off, she realises that she can trust no-one - friend or stranger - as this comatose killer moves in and out of bodies at will, getting ever closer as his murderous supernatural powers increase.

Having been promised the ‘trip’ of a lifetime by their Irish friend and mushroom expert Jake, a group of American teenagers arrives in Ireland, keen for adventure. Despite Jake’s warnings about the ’shrooms they shouldn’t eat, things start to go horribly wrong and the teenagers suffer horrific visions. The panicked friends are attacked by ghostly creatures, never sure whether they are experiencing gruesome reality or startling hallucinations. As the group is bloodily whittled down to one, it is soon clear that, whether or not these apparitions are real, the carnage they leave behind certainly is.